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Our in vitro data revealed that cellular machineries responsible for cardiac relaxation such as SERCA and phospholamban were downregulated and upregulated, respectively, in response to lethal toxin exposure.
The question then arises: how would parasites sense the environment to activate signaling machineries responsible for the control of their growth and differentiation?
In many cases the molecular machineries responsible for the distinct vesicular trafficking steps have been described in great detail.
This finding supports the idea that the machineries responsible for dynamic changes in gene expression variances and correlations during neural differentiation are conserved between humans and mice.
The balance between enzymatic machineries responsible for establishment, maintenance and removal of histone PTMs significantly contributes to chromatin dynamics in stem cells and is indispensable for driving cell-type specific biological outcomes.
These results, together with others [ 54, 55], support the notion that the machineries responsible for regulating mRNA levels as well as mRNA translation can remain largely independent of each other.
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This observation suggests that D. melanica may be pre-adapted to fish predation, and that the genetic machinery responsible for adaptive phenotypic plasticity in response to fish kairomone is ancestral in this species.
These, in turn, that activate the cytoskeletal machinery responsible for endocytosis and (possibly) for cell activation responses.
These include ion channel activity, which underlies the electrical signal produced in response to glucose stimulation, Ca2+ influx and the exocytotic machinery responsible for the release of insulin granules [ 38, 39].
Intrinsic defects in the endocytic machinery responsible for HER2 downregulation correlate with unresponsiveness to trastuzumab therapy34.
Here I consider the logical structure of the machinery responsible for these two activities.
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