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The lack of protein turnover machineries implies that the lens proteins are required to maintain their solubility and stability for several decades (Bloemendal et al., 2004).
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The cell type-specific molecular diversity of the epithelial ACh synthesis and release machinery implies that it is differently regulated than neuronal ACh release and can be specifically targeted by appropriate drugs.
Moreover, we found that the proteasome mediates early degradation of BRCA1, BARD1, BACH1, and Rad52 implying that critical components of the homologous recombinaion machinery need to be functionally abrogated as part of the early response to UV or MMS.
These data definitively show that the HT motif can be utilized by P. berghei in exporting proteins to the erythrocyte cytoplasm and implies that the machinery for HT-dependent export is conserved throughout the genus Plasmodium.
The evolution of each of the components of the meiotic machinery early during eukaryotic evolution implies that the interactions among the proteins included in our inventory also predate the divergences of the organisms included here.
The weight of evidence, therefore, implies that the machinery for local translation is present in peripheral sensory fibers, particularly A-fibers.
Similarly, Kirn implies that the "narrative machinery" mentioned by Wood as being somewhat unwieldy also produces a largely superfluous storyline.
This implies that the apoptotic machinery per se was intact in these cells and that the resultant refractory response to etoposide could be the result of ineffective communication between the machinery of the DDR with that of apoptosis (exemplified by sample UHN_0401, Figure 4C).
This implies that the translation machinery can adapt to the lack of EF-P modification.
The inability of both wt-AR expression and targeted knockdown of the endogenous mutant AR to affect the growth of E006AA cells implies that the AR signaling machinery is deficient in E006AA cells.
The finding that fusion of ubiquitin to a post-translationally inserted PM resident reporter is sufficient to trigger its internalization implies that plants possess an endogenous machinery capable of recognizing and sorting ubiquitin-tagged cargo.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com