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The high-titration case showed a small decrease in the incidence of MACE compared with that in the main study, and the low-titration case showed a slightly increased incidence of MACE compared with that in the main study.
Therefore, bezafibrate/statin treatment was a safe and was associated with a lower incidence of MACE compared with statins alone.
Both groups had similarly increased risk of long-term MACE after AMI and significantly higher incidence of MACE compared with non-diabetic patients including IGT patients.
The main purpose of the analysis was to examine whether post-challenge classification is a significant predictor for MACE compared with fasting glucose classification.
AMI patients with high admission MAGE (≥3.9 mmol/L) levels had a significantly higher incidence of MACE compared with low MAGE level patients (24.1 vs 8.4%; P = 0.001).
The Hypertension Optimal Treatment (HOT) trial studied whether the addition of aspirin to antihypertensive treatment reduced the risk of MACE compared with placebo [ 14, 15].
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Mean persistent hyperglycemia was 9.0 ± 2.8 mmol/L in patients with MACE compared to 8.1 ± 2.0 mmol/L in event-free patients (P < 0.0001).
Mean glucose during the first two days after admission was 9.0 +/- 2.8 mmol/L in patients with MACE compared to 8.1 +/- 2.0 mmol/L in event free patients (P < 0.0001).
It is notable that hip replacement was not associated with higher hazard ratios for 30-day risk of mortality or MACE, compared to knee replacement.
From the possible associated variables evaluated, HbA1c, CRP, systolic blood pressure and angiographically proven CAD were significantly different in patients who developed MACE as compared with those who did not.
In the first quintile, use of revascularisation was associated with the lowest rates of MACEs as compared with medical therapy (15% vs 28.7%).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com