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The hospital where the rhesus macaques were treated is located some distance from the biosafety level 3 lab where the vaccine research took place.
Evidence supporting this approach includes the observation of neuronal injury reversal in this model, which occurred when macaques were treated with combination anti-retroviral drugs that did not penetrate the CNS [19].
Cynomolgus macaques were treated humanely and with regard for alleviation of suffering.
Six SIV-infected rhesus macaques were treated with MVC monotherapy for 5 months beginning 24 days postinoculation; 22 SIV-infected animals served as untreated controls.
In this report, SIV-infected macaques were treated with MVC to evaluate the impact of CCR5 inhibition on SIV-induced CNS disease independent of other antiretroviral therapies.
Sections from basal ganglia region of macaques were treated with rabbit polyclonal PDGF-B antibody (Santa Cruz Biotechnology), followed by treatment with Alexa Fluor 594-conjugated anti-rabbit secondary antibody (1 : 500; Invitrogen) for 30 min at room temperature and mounted in Slow Fade anti-fade reagent with 4,6-diamidino-2-phenylindole (Molecular Probes, Eugene, OR, USA).
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In this model, macaques are treated daily with a low dose of MPTP until Parkinsonian motor abnormalities appear and reach an empirically defined threshold of behavioral impairment.
Thus, EPCs were identified as CD31+/CD133+/CD45 weak and measured in six bonnet macaques that were treated daily with ATN-224 (0.5 mg kg−1, s.c).
Macaque monkeys were treated with an antibody isolated from a human Ebola survivor and developed almost complete protection against a lethal dose of Ebola when the antibody was delivered up to five days after being infected with the virus.
Female macaques (Macaca fascicularis) were treated with a single dose of TCDD (4 μg/kg b.wt).
Forty-eight infant rhesus macaques (30 days old) sensitized to house dust mite (HDM) were treated with two week cycles of FA, house dust mite allergen (HDMA), ozone (O3) or HDMA/ozone (HDMA + O3) for five months.
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macaques were inoculated
macaques were divided
macaques were housed
macaques were challenged
macaques were scored
macaques were infected
macaques were elevated
macaques were subjected
macaques were assessed
macaques were grouped
macaques were left
macaques were prepared
macaques were performed
macaques were observed
macaques were stimulated
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