After informed consent was obtained, a questionnaire designed to elicit demographic data as well as data describing the frequency and type of exposure to Sangeh's macaques was administered in Bahasa Indonesia, the national language of Indonesia.
Post-mortem DAT binding was conducted in normal and MPTP-treated macaque monkeys that were administered L-DOPA, acutely or chronically.
One female (Animal #1, 2 3 years old) and one male (Animal #2, 2 3 years old) cynomolgus macaque (Macaca fascicularis) were administered cuprizone and rapamycin per os as a voluntary dietary supplement.
Two live, attenuated strains of Venezuelan equine encephalitis virus (VEE), IE1150K and V3526, were administered to macaques to determine if they could elicit protection against an aerosol challenge with virulent VEE virus of the IE variety (VEEV-IE).
TLR3 and TLR7/8 agonists (emulsified in Montanide) were administered subcutaneously to rhesus macaques at 48 hours and 7 days after DENV infection.
To investigate the potential of the DARPin application in vivo, DARPins 57.2 or E3_5 were administered via intravenous injection to clinically stable, SHIV-RT infected macaques (available from other completed studies).
500 CFU of M. tuberculosis Erdman (validated stock from FDA) in 2 ml PBS were administered into the right caudal lung lobe of each macaque using bronchoscope (Olympics) in BRL Annex BSL3 monkey facility, as we recently described [21].
In order to test the safety and biological activity of AAV-CFTR, single doses of AAV-CFTR vector were administered by fiberoptic bronchoscopy to the posterior basal segment of the right lower lobe (RLL) of the lungs of 10 rhesus macaques with four matched vehicle-treated controls.
Doses were administered by nurses.
Sera from four Rhesus macaques before and four weeks after being administered with YFV were incubated with melanoma cells from two randomly selected patients: immune reactivity was observed at indirect immune-fluorescence in most apes post vaccination [Hunsmann & Krone 2005. Vaccination against malignant melanoma. European Patent EP1586330A1].
