In chronically infected macaques, DermaVir administered with antiretroviral drugs, suppressed viral load rebound after treatment interruption and improved survival.
Following the promising results of their Phase I/IIa clinical trial and to evaluate the benefit of further "booster" immunisations, 17 patients were recruited into a Phase II clinical trial to assess the safety, immunological impact and clinical outcome of pTVG-HP, administered with rhesus macaque GM-CSF (rhGM-CSF) as an adjuvant, in patients with non-metastatic castrate resistant disease [99].
Sera from four Rhesus macaques before and four weeks after being administered with YFV were incubated with melanoma cells from two randomly selected patients: immune reactivity was observed at indirect immune-fluorescence in most apes post vaccination [Hunsmann & Krone 2005. Vaccination against malignant melanoma. European Patent EP1586330A1].
Control mice were administered with plain PBS.
Four subcutaneous injections of the botulinum neurotoxin light chain A1 (BoNT/A1-L) (MetabInc.gics Inc., Madison, Wi, USA) were administered with a one month-interval, except for the fourth injection given with an eight-month interval, to a male cynomolgus macaque (Macaca fascicularis).
In one approach, rhesus macaques were administered either alcohol or a sugar solution with the same calorie content directly into the stomach.
The protective effect of a therapeutically promising oral protease, EP-B2, was evaluated in a gluten-sensitive macaque by administering a daily gluten challenge with or without EP-B2 supplementation.
CH22 administered to macaques was able to protect against infection with SHIV BaL P4 (Haynes BF and Santra S, personal communication), extending similar work reported earlier (Watkins et al., 2011) and providing new data on the breadth of reactivity and the protective effects of V3 Abs.
Two live, attenuated strains of Venezuelan equine encephalitis virus (VEE), IE1150K and V3526, were administered to macaques to determine if they could elicit protection against an aerosol challenge with virulent VEE virus of the IE variety (VEEV-IE).
To determine if dietary gluten is a trigger of the clinical and serological condition described above in rhesus macaques, we successively administered 2 modified diets (reduced gluten and gluten-free) to FH09, an AGA+ juvenile macaque with chronic diarrhea, as well as to FR26, an age-matched AGA- control macaque that experienced no gluten sensitivity.
When administered together with synthetic double-stranded RNA, polyriboinosinic:polyribocytidylic acid (poly IC) or its analogue poly IC stabilized with carboxymethylcellulose and poly-L-lysine (poly ICLC), as adjuvant, HIV gag-p24 within anti-DEC-205 mAb is highly immunogenic in mice, rhesus macaques, and in ongoing research, healthy human volunteers.
