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This multistage study was designed to investigate a novel approach to predicting patients' response to cetuximab in mCRC.
Treatment policies for metastatic colorectal cancer (CRC; mCRC) are similar in Japan and in Western countries.
Therefore, there is an urgent need to develop new strategies to identify patients whose tumors could respond to and clinically benefit from anti-EGFR therapy in mCRC.
Pommier, A. J. et al. Serum protein profiling reveals baseline and pharmacodynamic biomarker signatures associated with clinical outcome in mCRC patients treated with chemotherapy ± cediranib.
A Topoisomerase 1 (Topoisonison is frequently included in the treatment regimens for metastatic colorectal cancer (mCRC).
Combinations of fluoropyrimidines with oxaliplatin or irinotecan plus a biologic agent are standard treatments for metastatic colorectal cancer (mCRC).
Activity was noted in mCRC.
Three of seven chemorefractory metastatic colorectal cancer (mCRC) subjects experienced PR; 8 of 15 chemonaive mCRC subjects experienced PR.
Skin toxicity associated with mCRC treatments was reported to have little impact on HRQoL among mCRC patients [56, 58].
CONCLUSION: Readmission is common after liver resection and/or ablation for mCRC.
XELOX Q3W remains the preferred schedule for the management of mCRC.
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