Exact(5)
However, it must be emphasized that the number of circulating lymphocytes may not always correlate with their number in the affected tissues or their in vivo functional activity.
Jiranek et al. [ 9] observed a macrophage and giant cell inflammatory reaction to particles of polymethylmethacrylate debris in mice with various levels of immune deficiencies, documenting that lymphocytes may not be necessary in a pure, nonspecific particle reaction.
In addition, disease responses in lymphocytes may not mirror many of the disease processes occurring in brain, which depend on the alteration of the blood brain barrier and the microenvironment represented by glia and microglia.
Two months after treatment with the retraction of his liver and spleen, the number of CD4+ T lymphocytes rapidly increased to 200/µL, which suggested that the low CD4+ T lymphocytes may not only be related to HIV-1 infection, but that VL may play an important role on the patient's suspected immunodeficiency status.
It should also be noted that previous examinations of muscle biopsies from IIM patients have found fibers that were positive for IL-1α, TNFα, and IL-1β staining, suggesting that lymphocytes may not be necessary to induce overexpression of IL-6 [ 29, 30].
Similar(3)
CXCL13 (CXC chemokine ligand 13; BCA-1), a chemo-attractant for B lymphocytes, is down-regulated in these mice, suggesting that B-lymphocytes may not be attracted to the CNS.
The use of isolated peripheral blood lymphocytes may well not be fully representative for all individual organs that are differentially afflicted by MCADD or VLCADD.
In addition, all mice immunized with VSVΔG/ZEBOVGP survived challenge with MA-EBOV even when depleted of CD8+ lymphocytes, suggesting that the cytotoxic T lymphocyte response may not be required [40].
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com