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In quiescent human T lymphocytes, for instance, H3.3 is the only H3 variant synthesized and is the major variant by mass (73%) (Wu et al., 1983).
T lymphocytes, for instance, promote bone loss in inflammatory arthritis by expressing RANK-L that directly binds and activates osteoclasts [ 24].
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Lymphocyte transformation assay potentially offers a sensitive indicator for several conditions involving lymphocyte dysfunction due, for instance, to immunologic deficiency [ 8].
For instance, lymphocytes [19] and fibroblasts [20] [22].
Eotaxin induces chemotaxis of other cells wearing CCR3, for instance lymphocytes and basophils [ 27].
For instance, lymphocytes present in the tumour might not always be active, due to immune escape or tolerance.
For instance, the lymphocytes from SLE patients displayed gene hypomethylation when compared to normal controls.
For instance, in lymphocytes, microgravity affected protein kinase C [ 10, 11], influenced NF-kB and MAPK-signaling [ 13], altered the expression of c-fos, c-myc and c-jun (summarized in [ 14]), reduced the expression of IL-2 receptor [ 21, 22] and decreased the capacity for the production of cytokines [ 23].
Corticosteroids and disease activity are known to affect circulating immune cell subsets, as for instance DCs or lymphocytes.
Besides their high turnover, immune cells fluctuate and only a minor portion is in the peripheral blood - for instance 2% of lymphocytes, while 98% are in tissues.
For instance, tumour infiltrating lymphocytes capable of killing autologous bladder tumour cells in 2D, failed to recognise targets when cultured in 3D (Dangles et al, 2002).
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