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The mechanism by which neutrophils, macrophages and lymphocytes enter the brain after ICH has received much less attention.
Following the early stimulation of the complement system and bleeding, activated neutrophils, macrophages and lymphocytes enter the wound area to remove pathogens and cellular debris.
In the next phase, inflammatory cells (mainly neutrophils and macrophages, but also lymphocytes) enter the wound site by chemotaxis (Jeffcoate et al 2004; Falanga 2005).
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In vivo imaging experiments have shown that lymphocytes entering the T-cell zones move randomly over densely packed networks of dendritic cells (DCs) and fibroblastic reticular cells (FRCs) [32], [33].
These parameters have been recently used to demonstrate in vivo adherence, as opposed to mechanical trapping, of lymphocytes entering lymph nodes.
Circulating naïve lymphocytes entering the lymph node through the high endothelial venule, and leukocytes entering inflamed tissues through venule capillaries, use a similar mechanism of transendothelial migration, as shown by the three-step Springer model [ 17].
Lymphocytes generally enter through specialized blood vessels called high endothelial venules (HEVs).
The nodes contain lymphocytes, which enter from the bloodstream via specialized vessels called the high endothelial venules.
Because only mature lymphocytes can enter the circulation, it is possible that this is done to protect immature cells from some aspects in the general circulation.
T lymphocyte progenitors enter the thymus via the bloodstream by using integrins, selectins and chemokines during periodically receptive times that are spatially and temporally regulated.
There is in fact a physiological barrier between bone marrow and blood which prevents immature lymphocytes from entering the circulation.
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