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Other members of the Ly-6 superfamily are involved in cell adhesion, cell migration, and the regulation of T lymphocyte regulation [ 28– 30].
This was reflected by induced expression of genes implicated in apoptosis and cell death mechanisms, presumably related to lymphocyte regulation and survival.
The other genes were implicated in apoptosis and thus might be a part of cell death mechanisms controlling lymphocyte regulation and survival.
In mammals, these genes are involved in cell death mechanisms and have been implicated in the control of lymphocyte regulation and survival.
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It was shown to be expressed in the thymic stroma [ 33] where it is involved in T-lymphocyte regulation and EFS-knockout mice develop exaggerated T-cell responses and inflammatory lesions [ 34].
Protein kinase D (PKD) has previously been implicated in lymphocyte integrin regulation through regulation of Rap1 activity.
The top 20 ranked GO terms for H3K4me1 in Broad-Enrich include leukocyte activation, lymphocyte activation, regulation of lymphocyte activity, positive regulation of immune response and regulation of leukocyte activation (Table 1 and Supplementary Table S8).
These findings may suggest that the generation of autoantibodies to citrulline related neoantigens could be closely linked to mechanisms responsible for impaired lymphocyte clonal regulation [ 34].
Consistent with a functional role for neurofibromin in control of murine lymphocyte growth regulation in spleen [ 26], we observed a statistically significant difference in spleen weights between wild-type and Nf1+/- animals.
IL-15 has numerous activities, including anti-apoptotic function, stimulation of T cell proliferation, generation of cytotoxic T lymphocytes, and regulation of NK cell survival and function, as well as the induction of immunoglobulin synthesis by B cells.
The ability of ATM to monitor the development of lymphocytes through regulation of both DNA repair and apoptosis plays a critical role in tumor suppression.
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