Cytogenetic laboratories are processing lymphocytes daily.
As lymphocyte cisplatin-DNA adducts are presumed to arise from exposure in vivo to free cisplatin, lower levels of adducts might have been expected as a consequence of the extremely low plasma free Pt levels post-SPI-77 and this may be a result of carry-over of liposomal Pt during Ficoll separation of lymphocytes and release during later processing.
They are capable of capturing, processing, and presenting antigens and thereby stimulating lymphocytes to a specific immune response.
It has been reported that dipeptidyl peptidase I (DPPI) is a granule protease that plays a requisite role in processing the proenzyme form of the cytotoxic T-lymphocyte (CTL) granule serine proteases (granzymes) [19] [22].
Artemis is an SNM1-like exonuclease that, upon complex formation with DNA PKcs, acquires endonucleolytic activity capable of processing complex DSBs, including the DSBs that occur in lymphocytes during V(D J recombination (Pannicke et al. 2004).
One subset of caspases is critical for regulation of inflammation by processing proinflammatory cytokines such as interleukin-1β; others are essential for lymphocyte activation, proliferation, and protective immunity (37, 38 ).
Head and neck cancer (HNC) cells express low HLA class I antigen processing machinery (APM) components, providing a major immune escape strategy from cytotoxic T lymphocyte (CTL -mediated lysis.
Apart from their role as scavengers (see the video of a macrophage consuming bacteria), macrophages play a key role in immunity by ingesting antigens and processing them so that they can be recognized as foreign substances by lymphocytes.
Red blood cell lysis and cell fixation using a Coulter QPREP specimen processing instrument (Beckman Coulter, FL, USA) were conducted, and more than 1 × 10 lymphocytes were counted using a BD FACSCalibur flow cytometer and CELLQuest software (BD, CA, USA).
"They are processing words".
