Exact(18)
Epstein Barr virus, a human herpesvirus, establishes a persistent asymptomatic infection of the circulating B lymphocyte pool [89].
In MSD/MUD-HSCT recipients, vδ2+ comprise up to 8% of the total lymphocyte pool, whereas vδ2+ T cells are barely detectable in UCB-HSCT recipients.
HCV NS3 exosomes appeared immunogenic when injected in mice, as proven by the detection of a memory CD8+ T lymphocyte pool two weeks after the last of three immunizations.
While the lymphocyte pool remained stable throughout Dex therapy, the proportion and the absolute number of circulating CD3−/CD56+ NK cells/mm3 significantly increased after 4 weekly vaccinations with Dex (Fig. 5B).
PCs are only a small fraction of the total B lymphocyte pool (about 1%).
A crucial question is whether these changes in thymocyte numbers translate into an altered peripheral lymphocyte pool.
Similar(42)
These analyses revealed that >80% of the CD4+/CD25+T lymphocytes were FoxP3+ in both mSOD1 and wild-type T lymphocyte pools.
We thus found a statistically significant correlation between the mean mutant load in each of the five lymphocyte pools and the heteroplasmy distribution at the single-cell level.
Comparison of the mean heteroplasmy rate vs one standard deviation of the heteroplasmy distribution at the single-cell level for each of the five lymphocyte pools (16.2 ± 8.6%) showed a 0.92 correlation coefficient (P<0.05) with a positive slope (1.14 ± 0.3) (Table 2 and Supp. Fig. S2).
Far from being an infection with a restricted distribution, EBV a gamma herpesvirus was found to be widespread in all human populations, in which it exploits normal physiologic processes to colonize the B-lymphocyte pool, persisting as a lifelong, asymptomatic infection.
Adequate IL-2 secretion is essential in naive CD4+ T cells proliferation in response to T cell receptor (TCR) stimulation and generation of effectors from naïve T lymphocytes pool [ 34].
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