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However the protein, called named lymphocyte expansion molecule (LEM), enables a much larger number of T cells to be produced – enough to overwhelm cancer or other kinds of diseases.
The important involvement of ROS to T cell metabolic fate and function was highlighted by the recent identification of lymphocyte expansion molecule (LEM).
Ourresearch objective was to design a new form of IL-7 that retained its capacity for supporting lymphocyte expansion without the need for a high dosing regimen.
Compared with the response to fast growing pathogens, the T-cell response to slow pathogens is delayed in its initiation, lymphocyte expansion is slow and the response often fails to clear the pathogen, leading to chronic infection.
For example, Notch regulates lymphocyte expansion and immune function [6], synaptic plasticity [7] and neural cell responses to injury [8] in the adult rodent brain.
Lymphocyte expansion can lead to infiltration of several organs, including the liver and bone marrow.
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In conjunction with earlier studies correlating clonal lymphocyte expansions with positive clinical outcome [26], this suggests an anti-leukemia role for clonal GDTc in vivo.
So, CD4+NKG2D+ T lymphocytes expansion seems to have an oligoclonal or monoclonal repartition, the significance of which at this point remains to be established (cf. infra: conclusion) (by immunohistochemistry, NKG2D expression on Mrs. XRL salivary gland tissue was not increased and was superimposable to CD8 expression but not to CD4's - data not shown).
Interactions between CD40 and CD40L provide critical costimulatory signals that trigger T-lymphocyte expansion (Grewal et al, 1998).
A very good example for this time window is the germinal center reaction of B-lymphocyte expansion and contraction that happens within approximately 21 to 28 days [ 90].
Sox4 null mice die during embryogenesis because of failure of endocardial ridge development, and blocking of B-cell lineage progression at the stage of pro-B-lymphocyte expansion [ 33].
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