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From these models, we derived the rates of HIV-1 RNA and CD4+ lymphocyte change from interaction terms between time and HAART initiation category (before, during, or after pregnancy).
We also performed secondary analyses of HIV-1 RNA and CD4+ lymphocyte change including variables for HCV sero-status and history of IDU on the subset of individuals for whom this information was available.
Linear mixed effects models [24] were used to calculate the rates of HIV-1 RNA and CD4+ lymphocyte change according to timing of first HAART initiation (before, during, or after pregnancy).
Outcomes of interest were rates of HIV-1 RNA and CD4+ lymphocyte change during the first 180 days of HAART initiation and HIV disease progression, which was defined as time to AIDS-defining event (ADE) or death at any time after HAART initiation.
Similar(56)
Dynamics of lymphocyte changes for individual animal are shown throughout the entire disease course in the Supplementary Figures S1 and S2.
Additional analyses of HIV-1 RNA and CD4+ lymphocyte changes repeated the above analyses excluding women on triple-NRTI HAART regimens, since such regimens are now not recommended despite their prior widespread use [25] [27].
All blood samples were drawn at 9 00-10 00 9 00-10 00 overnight fa.m.ng to after diurnal lymphovernightnges.
The clinically positive effects of lymphocyte changes were demonstrated, as well.
PB count changes are soon reversed, but some T lymphocyte changes may last for as long as 8 years [ 2].
The lymphocyte changes in the three family members carrying the GATA2 mutation stimulated investigation of bone marrow output.
Furthermore, lymphocyte changes associated with ambient PAHs in all but the B-cell fractions were greater in births where the mother or others around her smoked.
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