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This is in contrast to most previously published studies, which are based on lymphocyte biased data that underrepresents or excludes neutrophils (such as peripheral blood mononuclear cell [PBMC] samples), 6 or the use of a lymphocyte biased platform (ie, lymphochip cDNA platform).
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Khan et al (2011) suggest that the positivity findings in BC specimens may have been biased by EBV-infected lymphocytes.
Regardless of disease stage, the lymphocytes in multiple sclerosis plaques are biased toward the CD8 lineage—CD8 vs. CD4 T cells by as much as 10 to 1 (3).
Furthermore, the results may be biased by the presence of normal cells (for example, lymphocytes) within regions of invasive tumour that are more readily avoided when microdissecting pure DCIS because of the contained nature of the lesion.
4, 5 Therefore, the majority of studies examining gene expression changes associated with transplant rejection have used lymphocyte-biased samples or platforms such as peripheral blood mononuclear cells (PBMCs) 6 and Lymphochip cDNA microarrays.
highly biased.
"He'll be very biased, very biased.
These studies are, however, biased from the lack of a baseline value, and there is currently no clinical evidence of a detrimental effect of the proposed reduced lymphocyte count.
Therefore, the results were not biased by the anti-proliferative effect of 1,25D which would have been apparent if 1,25-VD had been added earlier during lymphocytes stimulation by PHA.
Sz and MF are defined by aberrations in four pathways: (1) evasion of activation-induced cell death, (2) TH2-biased lymphocyte differentiation, (3) TGFβ receptor expression and (4) modulation of TNF receptor ligands (reviewed in Dulmage et al).
Stress-induced alterations included an increased lymphocyte apoptosis, an anti-inflammatory cytokine bias and a reduced anti-bacterial response [8], [13].
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