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A special problem associated with identifying lymphatic involvement in rectal cancer is that lymph node size is not a reliable criterion for metastatic involvement because micrometastasis in normal-sized lymph nodes is common [ 65, 66].
We included ranges in uptake values and lymph node size.
Ultrasound, computer tomography and magnetic resonance imaging relay mainly on lymph node size.
Lymph node size may be correlated to immune infiltrates and not only to metastatic volume.
After treatment with doxycycline, we saw the strongest effects in down-regulation of CCR7 and reduction of lymph node size.
However, lymph node size and the presence of lymph node calcification did not predict PET result accuracy.
Four variables, namely lymph node size, lymph node location, PET scale, and presence of calcification were reviewed as factors predicting the diagnostic impact of PET.
Thus, it is tempting to speculate that the reduction in lymph node size after doxycycline administration is a result of CCR7 down-regulation.
Lymph node size is the dominant indicator.
The severity of synovitis correlated with draining lymph node size.
Therefore, single lymph node size is not a strong predictor.
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