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Notably in breast cancer, elevated expression of CD151 correlates with lymph node invasion and poor overall survival of patients with invasive ductal carcinoma [ 5, 6].
Lymph node invasion represents bad prognosis.
Lymph node invasion is the first step of metastatic evolution of prostate cancer.
However, none of these trials included patients with lymph node invasion (LNI).
Detection of lymph node invasion is performed by CT-scan and RMI, which show hypertrophied nodes.
However, node positive (N+) patients share heterogeneous outcomes according to the extent of lymph node invasion (LNI).
The role of extended pelvic lymph node dissection (ePLND) in treating prostate cancer (PCa) patients with lymph node invasion (LNI) remains controversial.
Preoperative assessment of the risk of lymph node invasion (LNI) is mandatory to identify prostate cancer (PCa) patients who should receive an extended pelvic lymph node dissection (ePLND).
According to the TNM staging system, patients with prostate cancer (PCa) with lymph node invasion (LNI) are considered a single-risk group.
All previous studies addressing the ability of CT scan to predict lymph node invasion (LNI) were based on historical patients treated with limited pelvic lymph node dissection (PLND).
The overexpression of synuclein-gamma is correlated with perineural and lymph node invasion.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com