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We identified potential −35 and −10 sequences and a dyad symmetrical sequence lying upstream of pMR68 merR and upstream of merT1, respectively; these sequences may represent putative promoters of the mer operon of cluster 1 in pMR68.
The PDX1 gene lying upstream of TDH3, had a clear termination defect in the rna15-2 strain, but was unaffected by the S411A or npl3-120 mutations (Figure 5B).
Sequence conservation of the HRE lying upstream of Drosophila fgaB transcription initiation site and the mammalian PHD3 HRE –localized in its first intron- [23] is remarkable, and extends beyond CGTG HRE invariant core.
The allele-specific pattern is due to the epigenetic switch of an insulator/transcriptional activator lying upstream of H19 (5), designated as the differentially methylated domain (DMD).
26, 27 In the VSG system, the unstable, 70-bp repeats lying upstream of the expressed VSG are thought to precipitate a high level of recombination (see below).
A 6400 bp BamHI/BamHI genomic fragment lying upstream of the DUSP6/ MKP- 3 start codon and including the putative transcriptional start site was cloned into pGL3Basic.
Similar(46)
LY-294002 (50 μM) was used to block the activity of PI3-kinase, which lies upstream of the mTORC1 complex.
RhoA lies upstream of MLC-2 and controls MLC-2 activation.
They may bind directly to special "promoter" regions of DNA, which lie upstream of the coding region in a gene, or directly to the RNA polymerase molecule.
In the control of the AER, Wnt3 lies upstream of BMP ligands (Barrow et al., 2003) and Dkk1 interacts with BMPs in this context, as they can mutually induce each others expression (Mukhopadhyay et al., 2001; Grotewold and Rüther, 2002).
The region of peak association lies upstream of LOXL1-AS1, a long non-coding RNA (lncRNA) encoded on the opposite strand of LOXL1.
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