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As with αvβ8, expression of αvβ6 in invasive tumors of the breast and lung supports the concept of an immunosuppressive role for αvβ6 via local activation of latent TGFb at tumor margins (Thomas et al., 2006; Xue et al., 2001).
Our finding of consistent, intense IHC staining for WNV in sections of small intestine and lung supports the possibility of oral transmission, as well as gastrointestinal and respiratory shedding, of the virus in free-ranging AMCRs, as suggested by others [ 11, 17, 30, 33- 35].
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extracorporeal lung support.
Extracorporeal lung support (ECLS) can be an additional lifesaving tool.
Also, in this study the indication for extracorporeal lung support was lung failure.
However, management of anticoagulation in ARDS patients with extracorporeal lung support is not clearly defined.
Argatroban was started at a median of 64 (36; 205) h after initiation of extracorporeal lung support.
Therefore, generalization of these results to other patients undergoing extracorporeal lung support requires considerable caution.
Both argatroban and heparin reached therapeutic aPTT values for adequate application of extracorporeal lung support.
Although such events are a major complication of extracorporeal lung support therapy, data on the clinical significance are sparse [23].
Therefore, this study assessed the feasibility, efficacy and safety of argatroban in critically ill ARDS patients undergoing extracorporeal lung support.
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