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If VILI is dependent upon the lung position, will a positive end-expiratory pressure (PEEP) be protective in all lung areas?
To our knowledge this is the first study to directly visualize the influence of lung position on alveolar instability caused by injurious MV.
Lung tumor development was followed once a week by bioluminescence imaging, taking a photo of upper dorsal region that corresponds to lung position.
We also assessed whether the 'time to alveolar instability' could be modified with the lung position (that is, nondependent versus dependent lung regions) and with increased PEEP.
In this study, we asked the following questions: what is the effect of the lung position (dependent lung versus nondependent lung) on the rate at which VILI occurs in the normal lung?
Animals were separated into four groups based on the lung position and the amount of PEEP: Group I, dependent + low PEEP (n = 5); Group II, nondependent + low PEEP (n = 4 Group III, dependent + high PEEP (n = 5); and Group IV, nondependent + high PEEP (n = 5).
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Furthermore the fetus was characterized by a low implant of the left ear, a severe scoliosis, and a hypoplastic right ribcage with both lungs positioned in the left ribcage.
We have proposed 4D digitally reconstructed radiography (DRR) for verifying a lung tumor position during VMAT [ 63].
Across the central to posterior portions of the lung supine position in particular has a very consistent relationship of around 1.2 to 1.4.
Atelectasis was always observed in the lung tissue positioned under the heart.
In isolated cases, personalized prediction of outcome is based on measurements of lung size, liver position, and the side of the defect [11].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com