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Recently, the previously mysterious lung pathogen pneumocystis also turned out to be a fungus and yields to anti-fungal treatment.
The cancer killer is a genetically altered lung pathogen and a member of the adenovirus family.
Indeed, a recent study showed that the CF lung pathogen P. aeruginosa is resistant to neutrophil-mediated extracellular killing, a process that is CFTR-independent [94].
C. pneumoniae has been shown to directly disrupt function of HIF-1a during infection of epithelial cells in vitro [30], which indicates that this lung pathogen may attempt to counteract the effects of A2b expression in actively infected cells.
Moreover, another study demonstrated that this NTM may be a lung pathogen [ 18].
For the pig lung pathogen Actinobacillus pleuropneumoniae, 15 serotypes with a considerable variation in virulence potential and immunogenicity have been identified.
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By demonstrating that one person's lungs can harbor both generalized areas of "healthy" microbiome and a single site containing a "pathogenic" community, our results suggest a mechanism by which the interaction of lung pathogens and host immunity might contribute to localized disease progression, even in the absence of overt exacerbation.
Most lung pathogens were bacterial (83.6%), and 57.9% were Pseudomonas aeruginosa.
The finding, in the March issue of the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine, fits well with recent theories about how humans fight off lung pathogens like the tuberculosis bacterium and why rates of asthma are increasing in the industrialized world.
This may explain the higher susceptibility of preterm infants to respiratory infections, as a robust autophagy response is essential for clearance of common lung pathogens like Pseudomonas aeruginosa (Pa).
Methicillin-resistant S. aureus (MRSA) and P. aeruginosa comprise the top two causative organisms of VAP and are considered particularly devastating lung pathogens as they cause persistent pneumonia infections, are resistant to a number of antimicrobials, and are associated with a high attributable mortality of patients with VAP [7].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com