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The exclusion of these women introduces a bias called verification bias, since women with low fetal lung maturity test results were more likely to be excluded than women with normal or high fetal lung maturity test results [ 8].
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Whether invasive testing for fetal lung maturity is useful, will depend on the effectiveness of expectant management as compared to immediate delivery in fetuses of which lung maturity tests have indicated mature lungs.
We therefore tested the hypothesis that fetal lung maturity testing does not predict the absence of morbidity in late preterm infants.
The maternal data were compared with the neonatal data to determine whether distress syndrome had developed in an infant who had undergone fetal lung maturity testing respiratory.
The objective of the study was to evaluate the performance of automatic quantitative ultrasound analysis (AQUA) texture extractor to predict fetal lung maturity tests in amniotic fluid.
When the results of fetal lung maturity tests are divided in 'mature' and 'immature' results, which is done in most studies on fetal lung maturity testing, the gradual maturation of the fetal lung is not taken into account.
Without fetal lung maturity tests, about 25 of the 157 women whose infant did not develop RDS could be identified as being at low risk.
In studies on fetal lung maturity testing, analysis is often limited to women who delivered within 72 h after amniotic fluid collection.
Clinical management of pregnancies was based on the maternal and/or fetal condition and on the outcome of the fetal lung maturity tests.
As a result, ACOG recently published an updated practice guideline that fetal lung maturity testing was not useful to guide delivery timing in medically indicated preterm delivery [ 27].
Moreover, an experienced neonatologist, who was unaware of the outcome of the fetal lung maturity tests, reviewed all chest radiographs of the infants with reported RDS.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com