For example, expression of VEGF-C in breast cancer cells increased intratumoural lymphangiogenesis and metastasis to lymph nodes and lung after injection into mice (Skobe et al, 2001b).
Therefore, there was a largest CdS accumulation in the lungs after injection intravenously into mice.
The results indicated that most of CdS were retained by the lungs after injection intravenously to mice, and the tissues of the liver, spleen, and kidney had also a certain degree of uptake; the largest accumulation were got at 6 h for the heart, liver, lungs, and kidney tissues (Fig. 5).
Each of the cell lines exhibited significant number of cells in the lungs post injection (Fig. 6A, right panel; data not shown).
Lung orthotopic injections are through the chest and directly into the lung [162], [163].
In a murine model only CXCR4 expressing, but not CXCR4-deficient CT-26 colon carcinoma cells grew into macrometastases; nonetheless both cell types were able to colonise livers and lungs after injection (Zeelenberg et al, 2003).
In mice treated with intratracheal bleomycin to induce granulocyte accumulation in the lungs, SAP injections reduced the number of granulocytes in the lungs.
Intravenously injected tumor cells mainly metastasize to the lung, whereas intracardiac injection enables tumor cells to spread systemically, including to the bone.
The highest biodistribution of oMWCNTs was found in the lung tissues post injection with 99mTc-oMWCNTs or 99mTc-oMWCNTs + NDs (Figures 2, 4, and 5), and higher distribution of NDs could be found in the liver and spleen (Figure 3).
We examined lung colonization following injection of B16F1 melanoma cells in IFNγ−/− mice compared with C57BL/6 controls.
