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While functional assessments are key end-points in clinical trials and disease staging in IPF [ 24], only a few small animal models of pulmonary fibrosis incorporate long term lung functional measurements into their protocols.
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For example, Stern et al. (2007) found that maximal expiratory flow at functional residual capacity measured in 123 infants at 2 months of age was associated with lung function measurements, including forced expiratory volume in 1 second (FEV1)/forced vital capacity (FVC), forced expiratory flow between 25%and75%5% of FVC (FEF25 75), and FEV1, up to 22 years of age.
An important following step would be to further examine these findings in additional panels of severe asthmatics, with subphenotypes of lung function measurements, blood eosinophils and most importantly atopic status to confirm the role of PDCD4 SNPs associations and clarify the functional relevance of the molecule.
Lung function measurements.
No lung function measurements were performed in LISA South.
Identical protocols were used for all lung function measurements.
All lung function measurements were pre-bronchodilator values.
Table 2 summarizes the lung function measurements at each age.
Lung function measurements were expressed as percentages of predicted values.
Spirometric lung function measurement is commonly used for the diagnosis, assessment, and management of lung diseases [20].
Warwick pulled out her latest lung-function measurements.
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