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Beside lung function improvement, liver function also improved from Day 18 with normalization of liver enzymes and coagulation factors.
Although GSTM5 had no functional SNPs, there was a significant lung function improvement in those who possessed the AA_CA diplotype, demonstrating a need to investigate this particular region.
It found a statistically significant lung function improvement for those on the study drugs.
About 30 percent who received Kalydeco and VX-809 had a lung function improvement of at least 10 percentage points.
In the data released on Monday, about 46 percent of patients who received the drugs experienced lung function improvement of five percentage points or more based on FEV1 — a measure of the maximum amount of air that can be exhaled in one second, Vertex said.
However, the lung function improvement did not seem to reflect on pulmonary mechanical properties.
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BID dosing may provide a 24-hour profile of lung function improvements that has the potential to improve the night-time, early morning and day-time symptoms of COPD that are common in patients with this condition [ 7, 8].
After 18 months, however, the lung function improvements did not differ between the groups.
There is evidence that lung function improvements are maintained for up to 1 year of treatment.
Results from the analyses reporting proportions of patients achieving lung function improvements for selected other endpoints (ITT population).
However, in contrast to the significantly greater lung function improvements seen with UMEC/VI versus FP/SAL, no treatment differences were seen for these endpoints.
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