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The recommendations about assessment of severe asthma follow the 2014 ERS/ATS task force guidelines [ 33], with the caution that the task force lung function criterion (a pre-bronchodilator FEV1 of <80% predicted in the previous year) may lead to over-classification of asthma as severe.
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Hence, "COPD populations" analysed in those studies that did not use lung function criteria may differ from people with COPD defined in accordance with GOLD criteria [ 24].
Acceptable lung function criteria included those of the Global Initiative for Chronic Obstructive Lung Disease GOLDD) [ 3, 4], the British Thoracic Society BTSS) [ 5], the European Respiratory Society ERSS) [ 6] and the American Thoracic Society (ATS) [ 7- 9].
Thus population-based cross-sectional studies using lung function criteria alone probably include cases with less severe disease than studies in hospitals or using mortality records.
These could be based on International Classification of Diseases (ICD) codes, on lung function criteria, on a combination of lung function criteria and symptoms, or on combinations of diagnosed conditions (such as CB or emphysema, or CB, emphysema or asthma), where diagnoses were extracted from medical records or reported in questionnaires.
We also found no association between this variant and lung function or smoking exposure in the lung cancer cases, the only group recruited independent of lung function criteria (Table 5).
Diagnosis of connective tissue disease will be made according to the rheumatological criteria for that disease; ILD in this setting will be diagnosed according to clinical/radiologic and lung function criteria, with lung biopsy in atypical cases.
The cohort study by Keddisssi et al. [ 26], the study by van Gestel et al. [ 21] and the RCT [ 19] applied lung function criteria (FEV1/FVC<70%) for the definition of obstructive lung disease.
Following the traditional practice of considering irreversible airway obstruction to be COPD, the COPD diagnosis was strictly based on the postbronchodilator lung function criteria without requiring documented exposure to a known causative agent.
Following the traditional practice of considering irreversible airflow limitation to be COPD, the COPD diagnosis was strictly based on the post-bronchodilator lung function criteria without requiring documented exposure to a known causative agent.
As some characteristics are correlated (e.g. mortality studies are often prospective, US studies are more often prospective than elsewhere, and studies using lung function criteria are commonly cross-sectional) it is not straightforward to identify underlying effects.
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