Exact(5)
This can be explained by the higher response rate with MMF in general and could shed light on why the LUNAR study of rituximab in SLE patients with proliferative lupus nephritis, which also used MMF, did not reveal clinical benefits.
However, the two large randomised controlled trials in extra-renal lupus (EXPLORER study) and lupus nephritis (LUNAR study) failed to achieve their primary endpoints.
To evaluate the safety and efficacy of rituximab in SLE in a clinical trial setting, two double-blind, randomised, placebo-controlled trials (DBRCTs) investigating renal (LUNAR study) and nonrenal (EXPLORER study) manifestations were undertaken (Table 2).
The planned efficacy margin in the LUNAR study was influenced by the 55% complete and partial response rate in the ALMS trial at 6 months using either mycophenolate or cyclophosphamide and corticosteroids.
The LUNAR study investigated the safety and efficacy of 2 × 1,000 mg rituximab, at both 0 and 6 months, as compared with placebo in addition to background therapy with high-dose glucocorticoids and mycophenolate mofetil 3 g/day in 144 patients with proliferative lupus nephritis, classes III and IV.
Similar(55)
(For additional information on lunar studies, see Moon).
He was active in lunar studies and produced two widely praised reports on dynamics (1857, 1862).
1970s-present Lunar studies are continued using samples returned by Apollo and Luna missions, meteorites originating from Moon, and data gathered by Earth-based mineralogical remote-sensing techniques.
LUNAR studied rituximab in patients with active proliferative nephritis, and all patients received concomitant mycophenolate mofetil (MMF) and corticosteroids [30].
Observations of the farthest boundary where energization of the ions takes place the bow shock are described by Yamauchi et al. For non-magnetized moons and planets, the role of localized magnetic field is also important, as presented in lunar studies by Halekas et al. and Saito et al. 2. What is the coupling between the incident plasma and the ionosphere/upper atmosphere or the surface?
Lunar studies also revealed that due to slight shifts in the orbital patterns of the moon around the earth, claims that "nights felt like they lasted forever" are in fact entirely accurate.
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