Sentence examples for luminal line from inspiring English sources
To understand whether the lethality observed for genes B is specific to A-deficient cell lines, we analysed the differential essentiality of B in the cell lines relative to the MCF7 cell line (due to lack of suitable data on normal cell lines, we chose MCF7 which is a typical luminal line with no known DDR defect, as our control for the comparison).
Instead, greatly decreased water consumption and the resultant abrasion of the luminal lining on ingestion of pelleted dry rodent chow is the most likely cause of the observed gastric and duodenal lesions following H2O2 administration in drinking water.
By expression patterns, most of the luminal lines most closely resembled either luminal-A or luminal-B tumors.
Despite incongruent expression results, luminal lines with amplification/overexpression of ERBB2 are likely appropriate models of ERBB2-associated tumors.
Interestingly, PTEN mutations were more common in the combined basal-like cell lines (P = 0.020), while PIK3CA mutations were more frequent in luminal lines (P = 0.022).
In contrast, basal-A lines appear mainly CD44+/CD24+, but express PROM1 (aka CD133), a marker of luminal progenitors in mice [86] also more recently characterized as a stem cell marker in BRCA1-associated breast cancer [87], while luminal lines express markers of luminal lineage restriction like GATA3 and FOXA1 [28].
Luminal lines displayed an estrogen receptor (ER) signature and resembled luminal-A/B tumors, basal-A lines were associated with ETS-pathway and BRCA1 signatures and resembled basal-like tumors, and basal-B lines displayed mesenchymal and stem/progenitor-cell characteristics.
In the remaining Luminal lines, AM580 and ATRA show similar efficacy.
Subsequently, the luminal lining was rinsed with PBS and flattened for imaging and micromotors counting.
In addition the basal-like cell lines showed greater temporal variation in expression than did the luminal lines.
In the ATRA-sensitive Luminal lines, AM580 is the only agonist which inhibits growth in a dose-dependent manner.
