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Calreticulin functions as a Ca2+ -binding chaperone and aids in maintaining Ca2+ homeostasis in the ER lumen of cells [ 67].
Of the utmost importance is accessibility from the lumen of cells, through which catalysts are easily transported.
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For example (see Table 3), cluster 1 groups biological functions together related to the lumen of cell organelles, especially relating to the nucleus.
Instead, blue fluorescence increased in the cell lumen of parenchyma cells in de-greened peels, which is typical for FCCs.
Clusters developed subsequently into alveolar-like cysts (ALCs), each comprising a central lumen devoid of cells enclosed completely by a monolayer of cells.
They also observed that siRNA-mediated depletion of HOXA1 in two other mouse mammary tumor cell lines resulted in more acinar (hollow) lumen formation of cells grown in matrigel.
Silicon is deposited as SiO2 · nH2O, either in intimate association with the organic components of plant cell walls or in silica bodies formed within the lumen of specialized cells [ 19- 21].
Soluble proteins that reside in the ER lumen of mammalian cells are prevented from secretion by retrieval from the secretory pathway back to the ER by KDEL receptor mediated recognition of a C-terminal KDEL sequence (Pelham 1991; Townsley et al., 1993; Munro and Pelham 1987).
Furthermore, human specific splice forms were found in three major tissues (liver, intestine and kidney) of known CEACAM1 expression and tissue staining for human CEACAM1 demonstrated the expected staining pattern, namely at the lumen of epithelial cells.
In any case, glucosylated glycan structures are present in the ER lumen of living cells as lipid-linked precursors in the ER membrane and, after the intervention of the oligosaccharyl transferase, as protein-bound tags that determine the fate of the associated polypeptide [34], [35].
Nevertheless, fluorescence signals were also detected inside the lumen of A549 cells, resembling either single particles or small particle agglomerates.
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