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The only gene that showed increased expression in NL vs LS skin was IL-37, a negative immune regulator [ 71], consistent with past reports [ 72].
Immune-related genes (e.g. CCL8, LCP2, CD1E) and IL-36G, which was recently associated with psoriasis pathogenesis [ 70], were increased in AD LS skin.
In LS skin, viral and innate immune process modules were significantly positively correlated with SCORAD, emphasizing the association between reactions to external pathogens and active inflammation in AD [ 121].
In LS skin, several networks showed significant positive correlations with SCORAD, including viral (M13) and innate immune response processes (M17), emphasizing cutaneous immune reactions to viral and/bacterial pathogens in LS AD skin.
It is established that AD LS skin shows alterations in lipid composition of the stratum corneum [ 109], with decreases in long-chain ceramides and free fatty acids in addition to disorganized lipid structure [ 107].
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Analyses were performed in 283 healthy individuals for whom both whole blood DNA methylation levels and gene expression profiles from the multiple tissues (the lymphoblastoid cell lines (LCL), skin, and adipose) were available.
The original AIDAI diary contains 13 items as follows: (a) fever ≥38°C (100.4°F); (b) overall symptoms; (c) abdominal pain; (d) nausea/vomiting; (e) diarrhea; (f) headaches; (g) chest pain; (h) painful nodes; (i) arthralgia or myalgia; (j) swelling of the joints; (k) eye manifestations; (l) skin rash; (m) pain relief taken.
Anode: (1) Ag + C l − ⟶ AgCl + e − Cathode: (2) AgCl + e − ⟶ Ag + C l − Skin extraction procedure was performed to determine the drug levels in skin.
Open image in new window Fig. 8 a and b Temperature profiles for different values of R and Pr, respectively Open image in new window Fig. 9 a Influence of β v and l on skin friction.
The GTEx consortium used RNAseq data from 29 solid organ tissues, 11 brain sub-regions, whole blood, lymphoblastoid cell lines (LCL) and skin fibroblast cells to study gene expression, including ASE within tissue.
Later studies undertook multi-tissue comparisons of cis-eQTLs including lymphoblastoid cell lines (LCL) versus skin cells [ 33]; LCL, skin, and fat [ 36]; liver, omental, and subcutaneous adipose [ 9], and re-analysis of the Dimas et al. datasets with new methods [ 37].
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