For hardware simplification, we implement only the position and intensity likelihoods LP and the intensity likelihood LI, while the similarity likelihood is dropped.
Headache severity pre-LP significantly influenced the likelihood of improving or deteriorating after LP.
CFA analyses were performed with Stata 12 (StataCorp. 2011. Stata Statistical Software: Release 12. College Station, TX: StataCorp LP) using a maximum likelihood minimization function.
When applied to other risk factors in coronary heart disease, this approach has previously confirmed the causal relevance of low density lipoprotein cholesterol, 9 increased the likelihood of causality for Lp(a) lipoprotein, 10 and reduced the likelihood of causality for fibrinogen.
Analyses were conducted using STATA 11.0 SE (StataCorp LP, College Station TX) to derive full maximum-likelihood and variance estimates with model assumptions confirmed through the analysis of residuals.
Regression models were fitted using Stata, version 13, statistical software (StataCorp LP, College Station, Texas), assuming a Poisson likelihood.
Model parameters were optimized using the Solver tool in Excel 2010 (Microsoft Corp., Redmond, WA) to maximise the objective (likelihood value) using the Simplex LP solving method.
The overall likelihood is taken as L = LP * LI.
Inferred relationships between genes were largely similar using the two approaches, although the relationship of LP 7 and LP 8 was unresolved using the Maximum Likelihood approach (data not shown).
However, asynchronous transfers might lead to inconsistent decisions due to the likelihood of simultaneous transfers of more than one LPs.
