It is important to emphasize that since the underlying sequences are relatively conserved these regions were not detected by the proposed evolutionary-constrained randomization since in this case permutation of lowly-variable columns doesn't produce enough variability in randomized variants.
We also showed a very low/not significant correlation between the levels of MFE related signal conservation and corresponding sequence variability values, demonstrating that conserved selection for local folding strength across different genotypes cannot be trivially explained by lowly-variable patterns in the synonymous codons and/or nucleotides preferences.
Thus, the lowly and moderately variable genes within genome vehicles play an important role in the formation of the neutrophil attractor (Figure 5E).
In addition, we demonstrate that the collective motion of lowly and moderately variable genes within the genome vehicle, which are often considered as noisy and insignificant, play an important role in the formation of the neutrophil attractor, perhaps indicating the non-instructive signaling of genes related to small-amplitude DNA motions [24] [25].
miRNAs highly expressed had more consistent levels among samples, while miRNAs lowly expressed were more variable which resembles the behaviour of genes as observed in a study that profiled the expression of 11,335 transcripts in lymphoblastoid cell lines from 210 humans [ 42].
In particular, lowly expressed transcripts in the RNAseq dataset had a variable range (high to low) of expression values measured by microarray.
On the other hand, Beclin1 stained normal cells and was heterogeneous in GBs, with a higher number of cases negative or lowly expressing the protein; a pin point cytoplasmic staining and variable nuclear immunopositivity were observed, 2(b), and 3(b)).
The same approach described above can be extended to control for two variables: for example, in order to compare allele frequency spectra between highly and lowly expressed sequences, 1 kbseqs couples were identified that displayed both similar GC content and recombination rate (less than 5%and10%0% difference, respectively) but extremely different expression levels.
A high proportion of these lowly expressed contigs may be derived from pea-specific repetitive elements, belonging to several sub-families which are highly variable in sequence and hence individually present in relatively lower copy number [ 2].
His beginnings were lowly.
