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The first one is defined as the exposure that would result in the lowest population risk while the second is the lowest imaginable exposure.
The EBD was estimated only for exposures above defined thresholds, if any, using a comparative risk assessment method based on a counterfactual exposure distribution that would result in the lowest population risk.
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Against a low population risk in these countries, the absolute recurrence risk is still low.
These abovementioned DTC genetic tests providers do not make a distinction between screening individuals with an a priori low population risk or testing individuals with a high a priori probability of having an affected child.
Study of gene-environment interactions may increase our ability to characterize relatively low population risks if a substantial proportion of the population cancer burden is attributed to high risk among a smaller group of genetically susceptible members.
We had previously found that average bed-days and between-group variance in bed-days are both low when population risk is low (data not shown).
39 40 We considered study design (cohort v case-control), study quality (high v medium or low), and population risk (high v low/unselected or unreported) as potential sources of heterogeneity.
This regular movement and the low population density also reduce risks of epidemic outbreaks.
The VIP belongs to a third generation of prevention programmes, introduced in the 1980s, which build on existing local structures, are small scale, action oriented and combine a broad low-risk population and high-risk individual strategies.
The combination of low-risk population and high-risk individual strategies creates opportunities for active participation and intervention by the general population.
However, some future RCTs may include design features (high or low methodological quality, high or low risk population groups, variants of the intervention, etc).
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