Sentence examples for lowest population frequency from inspiring English sources

The extent of this degradation can be estimated from a simple argument: The lowest population frequency entering our estimator is of the order u/(sic), while drift-dominated haplotypes will typically be at frequencies t/ N, where t is the time that has elapsed since the sweep.

This divergence could be related to specific population genetic background or to random chance in our results due to low population frequency.

Due to the low population frequency of the more recently described G2677A allele (<2% in Caucasians), this variant was not genotyped in the present study [28].

One of the alleles at each polymorphic site composing the significant haplotype had a low population frequency (pC = 0.08 for C871G; pT = 0.06 for C1177T), and was associated with short lifespan (Table 3).

Further evaluation of the known polymorphisms revealed a low population frequency for 4 of them.

All the SCL alleles with extreme number of codons added or predicted under nonstop decay have low population frequency.

A neutral mutation will take many generations until the mutated allele reaches a high or low population frequency.

Indeed, several studies on genes mutated at a low population frequency ('low frequency genes') have demonstrated that they can contribute to tumor formation or progression [ 38– 438.

The low population frequency of heterozygotes for the Hsp83 mutant allele, and in particular the near absence of mutant homozygotes in flies derived from wild populations, suggest that carriers of the mutant allele have lower fitness.

Therefore a replacement of one haplotype by a new variant (if needed) would appear to be a rare event in this instance, and one might expect a low population frequency of the gene variants involved.

HRRA can be extended to such situations to identify recent founder mutations even if the mutation may affect only a very small number of patients and the genetic variants have very low population frequency.