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These imaging conditions substantially reduce the dose to the sample by having a large pixel size and low exposure time, while still achieving high precision in locating atomic columns.
Fast clearing fragments, such as single-chain variable fragment (scFv; 25 kDa), with 1 antigen-binding site (monovalent) demonstrated low accumulation in tumors because of the low exposure time to the target.
28 Our model has a low exposure time to biochemistry-altering anesthesia (~7 min), is robust and technically simple.
TB results is probably due to both the low exposure time and the small number of participants, since these correlations have been demonstrated in many other studies [ 19, 23, 24].
Some degree of diffusional search is inherent to the system and cannot be captured even at our low exposure time of 0.56 ms, which is comparable to the positional autocorrelation time we measured (0.3 ms), and predicted theoretically (Craig and Linke, 2009).
The photon noise is mostly noticeable in the image when taking photographs in dark environments or at low exposure times.
Second, we are dealing with image noise, which is most apparent in images taken at low exposure times (or dark environments).
The investigation revealed uniform corrosion in comparison to inhomogeneous attack in case of ECA coated samples and reduced corrosion rates of around 20 µm/a even for low exposure times of 4000 h.
Thus we could use low exposure times (typically 200 ms).
The mCh3Myo5 signal was very faint and therefore was difficult to image at low exposure times.
As it is unlikely that a patient suffers from severe pain after short exposure time, it is assumed that the high discriminatory power at low exposure times is of a less practical importance than that at long exposure times.
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