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21 The fact that medications at the lowest dosing frequency improved inaccurate compliance for long-term treatment might also be supportive of our hypothesis.
Of the six patients enrolled in the next and lowest dosing level planned in the study, pazopanib 400 mg plus paclitaxel 175 mg m 2 plus carboplatin AUC5, two patients also experienced DLTs and the study was terminated.
Skin treated with the lowest dosing concentration of 0.34 μg/mL 20-nm washed Ag-nps typically showed a slight intracellular and intercellular epidermal edema; with 3.4 μg/mL of 20-nm washed Ag-nps there was moderate focal intracellular and intercellular epidermal edema and focal epidermal and dermal inflammation.
The monograph "Botulinum Toxin Type A for Injection" of the European Pharmacopoeia 7.2 (Council of Europe 2011) states that every production lot of BoNT has to be tested in an LD50 potency test in mice (Fig. 16), where the final dilution series results in the highest dosing killing 90% of animals and the lowest dosing in at least 90% survival.
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The best advice is to use the lowest dose for the shortest time possible.
Women are advised to take the lowest dose possible for the shortest period of time necessary.
Women are advised to take the lowest dose for the shortest time.
The lowest dose had the opposite effect.
Doctors should prescribe the lowest dose of Stendra that provides benefit, the FDA said.
Start with a low dose and use the lowest dose effective to avoid diarrhea.
His solution: low-dose hormone-replacement therapy.
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