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They say the drugs should be prescribed at the lowest dose required to treat a patient's insomnia.
The lowest dose required to cause clinical infection by inoculation (104 50% tissue culture infectious doses; 104 TCID50) was also the optimum dose for producing in-contact transmission.
OT control infusions were given at the lowest dose required for stable and submaximal contractions in each individual female.
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This property may contribute to the observed low dose required for protection.
The type A subspecies F. tularensis tularensis and type B subspecies F. tularensis mediasiatica are classified as a Category A agents because they are potential agents of biowarfare with a low dose required for lethality [1], [2].
The most likely mode of attack would be aerosolization; given the low dose required for infection (1 10 organisms), multiple cases would follow.
Indeed, administration of these compounds to mice did not induce whole body Fe-depletion or disturbances in haematological or biochemical indices due to the very low doses required.
On the other hand, if the administered chemical has unspecific toxicity, the low doses required contribute to the development of resistant parasite strains [10].
In the case of radiation induced genomic instability the physical properties of energy deposition by ionising radiation and the low doses required to initiate genomic instability indicate that the transition to instability is not a genetic effect and must therefore be epigenetic in character [22], [23].
The cross contamination highlights the tenacity of Salmonella and the low doses required for infection.
Conspiring to make E. coli O157 H7 an emerging threat in the international marketplace are its virulence and resilience, along with the relatively low doses required for infection, enabling ready transmission and enhancing opportunities for large outbreaks.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com