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Many metals have the lowest affinity for a support when they are in their most oxidized or most peroxidized state.
In keeping with these structural data-based predictions, we found that the HIF-2α peptides with the lowest affinity for pVHL are indeed class 1 mutants (L529P, A530T, P531A, Y532C; Fig. 4).
CA I and CA II were the most potently inhibited isoforms (KIs of 4 32 nM), whereas CA VA and VB showed the lowest affinity for these drugs (KIs of 5.4 20.2 μM).
Of all human IgG isotypes, IgG2 has the lowest affinity for FcγRI [27]; [28].
The A2BR has the lowest affinity for adenosine and is therefore likely activated under pathological conditions where adenosine levels are increased [48].
The EC50 for the peak current for C123, M123, C123, C123 and H123 were comparable with regard to the EC50 for charge: C123 and C123 showed the lowest affinity for 5-HT with an equal EC50 which differed significantly from those of all other receptor types.
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Ent2 exhibits a low affinity for guanosine and cytidine but a high affinity for inosine.
That part of the molecule facing the cytoplasm has a high affinity for Na+ and a low affinity for K+, while that part facing the outside has a high affinity for K+ and a low affinity for Na+.
The purified enzyme shows unusual kinetics with a low affinity for both substrates.
Some of them showed medium to low affinity for the BDZ-bs.
Indeed, the CLG peptide presents low affinity for HLA-A2 and does not produce stable complexes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com