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"This isn't a double-dip per se, it's just a soft spot, and very normal as economic growth takes a breather for a while and adjusts to new circumstances such as higher interest rates, lowering stimulus, or commodity inflation," he said.
A proposed mechanism of DOMS is that muscle nociceptors become sensitized in response to mediators of the inflammatory process, thereby lowering stimulus thresholds (peripheral sensitization) [ 6, 40].
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The mean threshold decreased very slightly from 8.13±0.35 dots to 7.97±0.39 dots (blue line: decreased by 2%; paired-t = 1.336, p = 0.2524) and 7.84±0.21 dots (red line: decreased by 4%; paired-t = 1.796, p = 0.1468) for the lowered stimulus brightness and the optical blurring conditions, respectively (Fig. 5A).
This push-pull effect becomes less by lowering the stimulus contrast [8].
It was previously shown that ACE-I is capable to augment classical [ 15, 16] and delayed preconditioning [ 17, 18] in WT animal models, by lowering the stimulus threshold.
In the LEPs recording sessions, we used a fixed intensity set at 2.5 times the individual sensory threshold, defined as the lower stimulus intensity that elicited a distinct painful pinprick sensation.
Furthermore, it was shown that migraine patients feel more stressed in all conditions tested (in general, during paced breathing and the mental stress test).This confirms earlier findings that migraine patients tend to react towards environmental factors more and with a lower stimulus threshold [24, 25], possibly associated with a higher sympathetic tone.
The cost of the lower stimulus package is that its effect was limited.
Response onset latencies were shorter for higher-intensity tones lengthening progressively with lower stimulus intensities (Fig. 1A B).
For each pair of cells, the lower stimulus intensity at which both (young and mature) neurons fired was selected for statistical analysis of spiking probability.
Moreover, asymptotic values were reached at lower stimulus intensities (≈0.07 mA for the Tg20 group vs. ≈0.16 mA for the wild-type group).
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