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Combinations of interventions should be considered as they may allow targeting different components of disease, thus lowering side effects while increasing efficacy.
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Information on these drugs is presented in Table 1 and the current therapeutic strategy is summarized in Table 2. Some drugs have a documented (modest) urate lowering side effect because of enhanced urate clearance by the kidney.
Pleiotropic natural products are one of the promising strategies due to their multi-targeting and due to lower side effects.
Designing of new ways of NM-based targeted drug delivery into cancer cells (targeted therapy) lowered side effects inflicted by many marketed drugs, such as doxorubicin and daunorubicin [115 117].
In recent years, interest in alternative therapies has been growing, and particular interest in plant sources is developing in light of their potential lower side effects, availability, and cost-effectiveness.
Therefore, the discovery of new anticancer agents from plant-derived substances is considered to be a highly promising approach in order to enrich the pharmaceutical field with effective drugs of lower side effects.
Benznidazole is the first choice for Chagas disease treatment due to its lower side effects than Nifurtimox.
To offer a greater therapeutic effect and lower side effects, it's necessary to discover a constant nanoparticle drug delivery targeting to subconjunctival fibroblasts in pterygium (PSFs).
Major advantages of hybrid anticancer drugs involved increased specificity, better patient compliance, and lower side effects along with reduction in chemo-resistance.
The therapeutic studies in human U87MG glioma xenografts exhibited that cRGD-HN-DOX in combination with NIR irradiation completely inhibited tumor growth and possessed much lower side effects than free DOX.
Pharmacokinetic and pharmacodynamic studies based on rat models suggested these newly constructed nanoassemblies with low cytotoxicity may function as novel nanoplatforms to efficiently and safely deliver therapeutics to achieve better efficacy but lower side effects.
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