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Efflux of hydrophobic TPP compounds by ABC transporters contributes to their lowered uptake into the brain and liver.
In silico simulations show that the associated morbid SNP erythrocyte has lowered uptake of dopamine and norepinephrine and lowered secretion of the methylated counterparts.
The lowered uptake can result in higher extracellular levels of glutamate, which can promote excitotoxic damage (Domercq et al., 2007; Matute, 2011) including neuronal swelling (Rossi et al., 2013).
Charging a nominal fee for such health products substantially lowered uptake, especially among the poor,, and distributing them for free did not make them more likely to be wasted by recipients.,, Once we determine "whether it works," RCTs can also help assess whether a public health intervention is effective on a larger scale to inform roll out of health policy.
Importantly, the observed lack of 1-indanone conversion is not caused by a poor expression because all PAMO variants were equally well expressed under these experimental conditions (data not shown), thereby pointing towards a low reactivity of PAMO P440L and P440G with 1-indanone like the wild-type enzyme and possibly a lowered uptake of the substrate under non-optimized conditions.
Similar(55)
This difference was entirely attributable to lower uptake in affected BRCA1 carriers.
bCo-injection significantly lowered the uptake of the same organ for the corresponding tracer (p < 0.05).
The other organs exhibited a lower uptake of radioactivity, generally between 2 and 5 SUV.
In CS, the lower uptake of 18F-FDG in the myocardium was evaluated.
A much lower uptake was observed in the A431-mock tumour.
Visualization of the lower uptake is even more demanding regarding the reconstruction protocol.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com