Pleiotropic natural products are one of the promising strategies due to their multi-targeting and due to lower side effects.
Combinations of interventions should be considered as they may allow targeting different components of disease, thus lowering side effects while increasing efficacy.
In the present study we noted a statistically nonsignificant tendency to lower Side effects of corticosteroids in the elderly, however there was no indication of a difference according to age in the Limited cognitive dimension or Increased growth of gum and hair dimension in the present study.
Information on these drugs is presented in Table 1 and the current therapeutic strategy is summarized in Table 2. Some drugs have a documented (modest) urate lowering side effect because of enhanced urate clearance by the kidney.
In recent years, interest in alternative therapies has been growing, and particular interest in plant sources is developing in light of their potential lower side effects, availability, and cost-effectiveness.
Therefore, the discovery of new anticancer agents from plant-derived substances is considered to be a highly promising approach in order to enrich the pharmaceutical field with effective drugs of lower side effects.
The TRV130 is specific pain relieving analgesic that has lower side effects, similar to PZM21 [16].
Zingember also induced lower side effects regarding itching and redness- i.e. it seemingly exerts a lower (p>0.05) thermal stimulus.
The in vivo anticancer experiment further revealed the pronounced anticancer effects and the lower side effects of the HFNDs.
In a recent study, Manglik et al. search for ideal opioid ligands that have lower side effects [13].
