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Moreover, autoimmune urticaria is associated with higher frequencies of wheals, higher disease activity score, prolonged disease course, and lowered responsiveness to H1-antihistamine.
Increased expression of TNFα protein was also detected the gut tissue of women by immunohistochemistry. CD8 T cells from women, despite having higher levels of HLA-DR compared to men, showed lowered responsiveness to non-specific stimulation.
Aging is characterized by a decline in regenerative capacity, which can be partially explained by changes in growth factors, accumulation of DNA damage, and lowered responsiveness of progenitor cells.
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Sexual problems can extend to lower responsiveness to touch, lower sex drive, and difficulty achieving orgasm.
Since CFR results also diverged in the study of Hermann et al. [ 26], we speculate that more severe microcirculatory dysfunction in diabetics with a high risk profile is responsible for this lowered endothelial responsiveness.
As we expected, the rs1800625 polymorphism is significantly associated with lower responsiveness of peripheral blood leukocytes in response to LPS stimulation, showing much lower levels of TNFα in patients carrying the variant C allele.
Our further study showed that rs1800625 was significantly associated with lower responsiveness of peripheral blood leukocytes in response to lipopolysaccharide (LPS) stimulation, showing much lower levels of tumor necrosis factor alpha (TNFα) in patients carrying the C allele.
Supporting our findings of a lower responsiveness of ERK1/2 in older muscle, ERK1/2 phosphorylation in response to high-frequency electrical stimulation was markedly blunted in aged rats compared with young rats immediately postexercise (19).
The lower MF response in mice treated with TOCP is not likely due to a lower responsiveness to airway irritants in the mice in general, since our control study revealed that TOCP treatment did not change the sensitivity to formic acid.
Depression/anxiety disorders are associated also to a lower responsiveness trend at limit of significance.
Accordingly, hyperlipidemia impaired glucose clearance during IC (1.58 vs. 2.72%/min), reflecting lower responsiveness to insulin.
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