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Our results revealed that percentage of pDCs changed according to anti-MICA-Ab positivity which in turn was associated with a lowered graft survival and higher acute rejection rates in previous studies [ 17].
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Patients who had a ≥50% dose reduction of MMF experienced a lower graft survival compared to those who tolerated full-dose MMF.
At lower graft density and larger molecular weight of the PHMA block, the nanocomposites exhibited simultaneous improvements in fracture toughness and tensile modulus.
A lower graft surface blood flow rate was revealed in the thalidomide treated NMRI nu/nu mice group compared to the vehicle group (percentage of graft flow rate to adjacent renal cortex: 60.6±3.5 vs 81.4±1.1, p<0.01; Figure 7B).
However, other authors describe different results with lower graft survival and increased mortality in patients with SLE [ 30].
In addition, they reported a lower graft survival at 10 years in patients with lymphocele compared with those that did not develop lymphatic complications (68.14 versus 76.36%) [ 43].
Rayhill and Roberts (abstract 396) reported that both greater donor age and donor BMI >30 were associated with lower graft survival.
It is a well-established fact that incomplete revascularization and lower graft patency have a negative impact on long-term survival.
In particular, in the long term, patients with DGF are 1.53 times more susceptible to graft loss at 5 years and have an overall 10% lower graft survival rate compared to EGF patients [ 23- 26].
In addition, DSAs were associated with lower graft survival in 5 out of 6 studies investigating this relationship [ 47, 50, 52, 57, 71], with 2 studies reporting significant differences between groups [ 71, 72].
Similarly, a recent study reported lower graft survival in sensitized patients compared with non-sensitized patients (1 year: 85% vs. 95%; 3 years: 75% vs. 94%; 8 years: 60.6% vs. 83%; P < 0.001) [ 57].
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