Sentence examples for lowered affinity for from inspiring English sources

Binding to GTP causes conformational changes within three flexible segments of Gα, namely "switch" regions (I III) leading to a well ordered, GTP bound activated conformation with lowered affinity for the Gβγ complex and increased affinity for downstream effectors.

Mutants displaying similar or higher binding affinities to DR4, together with a lowered affinity for DR5, were characterized.

A lowered affinity for the Fe(II) cofactor may impact apparent turnover numbers in the presence of Fe(II) in the assay, as described by Dominy [58].

However, the Antarctic octopod, Pareledone charcoti, was shown to mitigate this detrimental effect by an increased expression of a haemocyanin with lowered affinity for oxygen, and an increased rate of pH dependent oxygen release.

Because both of these mutations produce receptors with lowered affinity for IgG [ 11], it is thought that these variants may predispose to autoimmunity through delayed clearance of immune complexes, but this remains an unproven hypothesis.

The arrestin mutants with Trp residues in the 160 loop clearly inhibited transducin activation to an extent (80 90%) larger than that of the finger loop mutants (∼50%), perhaps because of a lowered affinity for the latter.

In FcγRIIIA, a valine for phenylalanine substitution (V176F, rs396991) lowers affinity for IgG1 and IgG3, and prevents binding to IgG4 (12).

This decrease may be attributed to its ≈ 10-fold lower affinity for hsst5.

Unexpectedly, the tri-amine grafted samples exhibited lower affinity for both metal cations.

Pyrrolidone 15 was found to exhibit reasonable affinity for PKCδ, with lower affinity for the other isozymes tested.

Subtle changes in cyclohexane stereochemistry and removal of functional groups led to analogues with lower affinity for the MC receptors.