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In contrast, a meta-analysis comparing four head-to-head studies did reveal a lower unsatisfactory rate for the SurePath platform.
This 'cleaning' of samples is often cited as the reason there are lower unsatisfactory rates in LBC. 1 The liquid platforms also allow for reflex testing for human papilloma virus for borderline cases.
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Negative factors in the sending countries include insufficient suitable employment, lower pay, unsatisfactory working conditions, poor infrastructure and technology, lower social status and recognition, and repressive governments.
47 The data presented here show a significant difference between the different platforms with SurePath having a significantly lower rate of unsatisfactory samples.
The DK crush procedure was characterized by more contrast use (P = 0·04), more balloons (P < 0·01), longer procedural times (P < 0·001), and a lower rate of unsatisfactory final kissing balloon inflations (27·63% vs. 6·3%, P < 0·01).
However, there remains a divergence of opinion on the advantages of LBC over conventional cytology, and a recent RCT found that LBC had equivalent sensitivity for ≥ CIN2 lesions relative to conventional Pap, but had a lower rate of unsatisfactory smears when compared with the latter[ 28].
The recommended dose of is 200 mg daily (100 mg bid), albeit increases in the dose up to 400 mg daily have been approved in cases in which the blood glucose-lowering effect is unsatisfactory [ 52].
It is often quoted that CRT has a 'non-responder' rate of up to 30%, implying that a responder rate of anything lower than 100% is unsatisfactory.
In general, the proportion of unsatisfactory samples is lower in LBC compared with conventional cytology, and the interpretation of LBC requires less time.
Notwithstanding the steady increase in organ donation, pancreas recovery rates remain unsatisfactory and much lower than those for other solid organs; e.g., >8,000 multiorgan donors were available through the United Network for Organ Sharing (UNOS) in 2006 (of these, ∼2,000 pancreata were recovered and only ∼1,440 used for transplant [ http://optn.transplant.hrsa.gov/data/annualReport.asp]).asp]
However, even this adapted Mason system was unsatisfactory when considering the lower limit of 95% of the confidence interval.
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