Sentence examples for lower therapeutic from inspiring English sources

To find an explanation for the lower therapeutic effect of the combination vs. single 177Lu-DOTATATE therapy, 177Lu-DOTATATE tumor uptake was quantified in tumors with and without RAD001 pretreatment.

A third option, metronomic therapy which postulates continuous treatment with lower therapeutic doses, might have less severe long-term side effects, but is not designed to prevent emergence of resistance [19].

In particular, addition of surfactants that reduce protein binding can modulate nanoparticle clearance by the immune system, but also screens the desired interactions with cells, leading to lower uptake, thus lower therapeutic efficacy.

Insufficient knowledge of the physiological changes and side effects that occur during mild (34°C to 35.9°C), moderate (32°C to 33.9°C), moderate-deep (30°C to 31.9°C), and deep (<30°C) hypothermia is likely to lead to lower therapeutic efficacy or even failure of treatment [15].

The small but measurable increased risk for ESRD in lithium-treated patients cannot be prevented completely but with the use of lower therapeutic lithium levels, monitoring of eGFR and judicious discontinuation of lithium when needed, this risk can be minimized and patients more effectively treated.

When the duty-cycle of therapy (or dose cumulant) is small, the lower therapeutic intensity can not afford to destroy the tumor cells substantially.

We report the electrochemical determination of urate lowering therapeutic drug, allopurinol (AP) using the electrochemically reduced graphene oxide (ERGO) modified glassy carbon electrode (GCE).

The lack of a definition of safety and tolerability of allopurinol maintenance doses above those previously calibrated for serum oxypurinol levels related to creatinine clearance [ 46] needs to be considered when weighing the decision to employ more advanced serum urate lowering therapeutic options.

In addition, particular phase I metabolites or breakdown products may elicit adverse effects on their own, which can lower the therapeutic window.

The experiment was similar to the tests performed in [26],[27] where the Anklebot, a multi-axis lower extremity therapeutic robot, was employed to apply pseudo-random torque perturbations to the ankle in DP and IE directions.

Therefore, in our presented case the expected lower daily therapeutic costs did not exist in practice.