However, their study incorporated a number of patients with severe sepsis (lower severity of illness compared with the current study), and did not report fluid management, which is an important determinant of survival in sepsis [ 54].
A subsequent trial - Administration of Drotrecogin Alfa (Activated) in Early Stage Severe Sepsis, or ADDRESS - targeted patients with lower severity of illness and could not demonstrate efficacy [ 15].
Our study cohort included patients who had severe sepsis rather than septic shock, with an associated overall lower severity of illness.
The 31 % of patients with physician-diagnosed severe sepsis who did not meet consensus criteria were younger, had a lower severity of illness, and a lower PICU mortality than those who met consensus criteria or both definitions.
It may therefore be appropriate for physicians to diagnose severe sepsis more often than consensus criteria, particularly in children with a lower severity of illness who may need fewer adjunctive sepsis-related therapies.
Patients with physician-diagnosed severe sepsis who did not meet consensus criteria were younger and had lower severity of illness and lower PICU mortality than those meeting consensus criteria or both definitions.
"The three recent cases in the UK represent an important opportunity to obtain more information about the characteristics of this infection in humans and risk factors for its acquisition, particularly in the light of the first ever recorded instance of apparently lower severity of illness in one of the cases," said Watson.
Lower severity of mucositis strongly correlated with higher adherence to the schedule of study drug administration.
In many cases, pupils who attend these schools have lower severity of disabilities than those that would require special educational support in special schools.
Humanized and human anti-CD20 mAbs are theorized to cause reduced incidence and lower severity of IRRs compared to rituximab due to decreased immunogenicity.
Although we expected the patients with short AKI to have lower severity of illness than patients with medium duration AKI, there were no differences between the groups with regard to comorbidities, AKI severity or general disease severity measurements.
