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As we expected, the rs1800625 polymorphism is significantly associated with lower responsiveness of peripheral blood leukocytes in response to LPS stimulation, showing much lower levels of TNFα in patients carrying the variant C allele.
Our further study showed that rs1800625 was significantly associated with lower responsiveness of peripheral blood leukocytes in response to lipopolysaccharide (LPS) stimulation, showing much lower levels of tumor necrosis factor alpha (TNFα) in patients carrying the C allele.
Supporting our findings of a lower responsiveness of ERK1/2 in older muscle, ERK1/2 phosphorylation in response to high-frequency electrical stimulation was markedly blunted in aged rats compared with young rats immediately postexercise (19).
The lower MF response in mice treated with TOCP is not likely due to a lower responsiveness to airway irritants in the mice in general, since our control study revealed that TOCP treatment did not change the sensitivity to formic acid.
Accordingly, hyperlipidemia impaired glucose clearance during IC (1.58 vs. 2.72%/min), reflecting lower responsiveness to insulin.
Depression/anxiety disorders are associated also to a lower responsiveness trend at limit of significance.
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On the other hand, CAR activation increases serum triglycerides and liver fatty acid synthesis, represses adaptation to hyperlipidemia, and lowers responsiveness of the liver to adiponectin.
Moreover, autoimmune urticaria is associated with higher frequencies of wheals, higher disease activity score, prolonged disease course, and lowered responsiveness to H1-antihistamine.
Aging is characterized by a decline in regenerative capacity, which can be partially explained by changes in growth factors, accumulation of DNA damage, and lowered responsiveness of progenitor cells.
Increased expression of TNFα protein was also detected the gut tissue of women by immunohistochemistry. CD8 T cells from women, despite having higher levels of HLA-DR compared to men, showed lowered responsiveness to non-specific stimulation.
In the face of the lower general responsiveness of human than murine cultures, responses to weaker stimuli were less readily detectable, perhaps explaining the lack of a significant stimulation by AR231453 in this study.
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